IndraLab

Statements

TNF increases the amount of THBD. 7 / 9
| 7
reach
"TNFα also induces catabolic processes in synovial joint and directly regulates intra-articular levels of FVIIIa modulating expression of thrombomodulin (TM) (Aggarwal et al., 2012; Wojdasiewicz et al., 2018)."
32581836
reach
"Suppression of endothelial thrombomodulin expression by TNF-alpha has been documented [XREF_BIBR]."
27408725
reach
"In vitro, tumor necrosis factor (TNF) induces endothelial expression of the procoagulant, tissue factor, and downregulation of thrombomodulin, a key component of the thrombomodulin and protein C (PC)/protein S (PS) pathway, which normally maintains an anticoagulant state by inactivating thrombin, preventing further thrombin formation by degrading factors Va and VIIIa, and decreasing plasminogen activator inhibitor activity."
1309855
reach
"Endothelial cell culture and animal studies have indicated that TNF-alpha and IL-1 enhance the pro coagulant response by down regulating expression of thrombomodulin and protein C synthesis [XREF_BIBR, XREF_BIBR]."
33875909
reach
"TNF and IL-1 promote blood coagulation by inhibiting the expression of thromboregulatory protein (TM) and reducing the production of activated protein C (APC), thus promoting the coagulation reaction [61,62]."
34094634
reach
"A major component of this response is a reduction in expression of thrombomodulin, a cell surface cofactor for the activation of protein C. Regulation of thrombomodulin expression by TNF has been reported to occur through multiple mechanisms."
1846763
reach
"TNFalpha and IL-1beta promote thrombosis at the vascular wall by inducing endothelial expression of tissue factor and downregulating expression of thrombomodulin, the endothelial thrombin receptor that plays a key role in the activation of the anticoagulant protein C pathway."
18561503