IndraLab

Statements

USP14 activates PI3K. 7 / 7
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"USP14 activates phosphatidylinositol-3 kinase (PI3K) via the Wnt/β-catenin-mediated pathway [55,56]."
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"It has been shown that USP14 induces PI3K/Akt signaling to enhance growth and metastasis of HCC."
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"USP14 activates phosphatidylinositol-3 kinase (PI3K) via the Wnt/β-catenin-mediated pathway [ xref , xref ]."
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"Moreover, USP14 can activate phosphatidylinositol-3 kinase (PI3K) to induce cell growth via Wnt/β-catenin pathway ( xref ; xref ), which also can contribute to the occurrence of drug resistance in CRC cells using USP22 ( xref )."
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"Moreover, USP14 can activate phosphatidylinositol-3 kinase (PI3K) to induce cell growth via Wnt/β-catenin pathway (Huang et al., 2015; Zhang et al., 2020a), which also can contribute to the occurrence of drug resistance in CRC cells using USP22 (Miao et al., 2022)."
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"Notably, USP14 can also directly deubiquitinate and activate PI3K and lidocaine can inhibit the expression of USP14 and the activation of PI3K/AKT in HCC, and significantly inhibit the proliferation, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Lidocaine inhibits the proliferation and invasion of hepatocellular carcinoma by downregulating USP14 induced PI3K and Akt pathway."
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