IndraLab

Statements

ERBB2 activates COPS5. 4 / 5
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"Also, HER-2 and neu activity causes mislocation of p27 and Jun activation domain binding protein 1 (JAB1), an exporter of p27, into the cytoplasm, thereby facilitating p27 degradation."
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"In contrast to our data and other interaction effects, these studies concluded that Her2 mediated Jab1 regulation occurs at the transcriptional level."
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"Promoter activity assay suggested that HER-2 and neu oncogene upregulated Jab1 via transcriptional activation."
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"HER2 has been found to stimulate Jab1 transcriptional activity in NIH3T3 cells stably expressing the HER2 receptor [XREF_BIBR]."
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