IndraLab

Statements

ERBB2 activates COPS5. 6 / 7
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"Promoter activity assay suggested that HER-2 and neu oncogene upregulated Jab1 via transcriptional activation."
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"In support of this, it has been shown that overexpression of Her-2/neu enhances p27 degradation and stimulates cytoplasmic accumulation of CSN5."
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"In contrast to our data and other interaction effects, these studies concluded that Her2 mediated Jab1 regulation occurs at the transcriptional level."
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"HER2 has been found to stimulate Jab1 transcriptional activity in NIH3T3 cells stably expressing the HER2 receptor [XREF_BIBR]."
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"HER-2 transcriptionally increases Jab1/CSN5 promoter activity through the AKT/β-catenin pathway, thus promoting the proliferation of breast cancer cells ."
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"Also, HER-2 and neu activity causes mislocation of p27 and Jun activation domain binding protein 1 (JAB1), an exporter of p27, into the cytoplasm, thereby facilitating p27 degradation."
10859299