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USP7 inhibits PARP1. 4 / 4
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"Furthermore, XREF_FIG showed that poly ADP-ribose polymerase (PARP) cleavage and cellular apoptosis were induced by USP7 inhibition."
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"Importantly, PARP cleavage and Bcl-2 downregulation induced by USP7 inhibition were attenuated upon ERα overexpression ( Fig. 7 C)."
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"We assessed the mechanism of action of nine drugs (Figure 10) and found that high levels of USP7 expression attenuated drug effects for; BRAF, MEK, TOPOI, and PARP."
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"The results of western blotting showed that PARP cleavage and downregulation of Bcl-2 were induced by USP7 inhibition ( Fig. 6 G–I)."
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