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UCHL3 deubiquitinates CTNNB1. 4 / 4
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"However, whether UCHL3 is involved in the deubiquitination of CTNNB1 and its role in bladder cancer remain unknown.The aim of this study is to elucidate the mechanisms underlying the impact of UCHL3 on the initiation and progression of bladder cancer and to identify potential targets for its treatment."
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"Subsequently, we evaluated whether UCHL3 is able to catalyze the deubiquitination of CTNNB1."
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"Therefore, UCHL3 might suppress the ubiquitin-driven degradation of CTNNB1 and thereby trigger the Wnt signaling pathway, resulting in tumorigenic promotion.Although the stabilization of UCHL3 depends on its deubiquitinating activity, UCHL3 directly deubiquitinates CTNNB1, and the sites of CTNNB1 that are deubiquitinated by UCHL3 need to be identified.In summary, we showed that UCHL3 expression is amplified in bladder cancer and functions as a tumor promoter that enhances the proliferation and migration of bladder cancer cells in vitro and to bladder tumorigenesis and tumor progression in vivo."
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"Furthermore, β-catenin ubiquitination was reduced by the binding of wild-type UCH-L3 (Fig. 2J)."
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