IndraLab

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USP15 inhibits DNA-templated transcription. 5 / 5
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"Ectopic USP15 expression deubiquitinates and stabilizes endogenous YY1 and thus suppresses HIV-1 transcription, while USP15-specific UbV inhibitors prevent endogenous USP15 from deubiquitinating YY1, thus promoting YY1 degradation and relieving USP15-induced inhibition of HIV-1 transcription."
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"Ubiquitin-specific peptidase 15 (USP15) can stabilize MDM2, as well as degrade transcription factor NFATc2, to regulate T-cell activation."
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"These findings together demonstrate that stabilization of YY1 protein by USP15 deubiquitinating activity contributes to USP15-mediated inhibition of HIV-1 transcription and may help the development of USP15-specific UbV inhibitors as an anti-HIV strategy."
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"These results collectively demonstrated the inhibitory effects of USP15 on HIV-1 gene expression and virus production and suggest the important roles of USP15 in HIV infection and pathogenesis.3.2 Ectopic USP15 expression repressed HIV-1 transcription, whereas UbV expression increased HIV-1 transcription."
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"Using the USP15 UbV inhibitors, we demonstrated that ectopic USP15 expression inhibited HIV-1 transcription, contributing to decreased HIV-1 gene expression and virus production, whereas expression of UbV, USP15 inhibitors, had opposite effects on HIV-1 transcription, gene expression and virus production."
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