IndraLab

Statements


USP4 ubiquitinates SMAD4. 2 / 2
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"The ubiquitin ligase Ectodermin/TIF1γ promotes, while the deubiquitinases USP9X and USP4 antagonize SMAD4 monoubiquitination [28,85,86]."

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"It may be noted that USP4 modulates the pathways of various TGF-β family members, such as BMPs (Bone morphogenetic proteins) and activin, by directly ubiquitinating Smad4 and, thus, preventing its deg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"