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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

KCNQ2 activates localization. 2 / 2

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"The wild type and R353G mutant channels were also found at the AIS and distal axons, regions where the A343D mutant channels and the CD4-KDEL proteins were absent (XREF_FIG), indicating that the A343D mutation in the IQ motif of KCNQ2 enhances the localization of HA-KCNQ3 and KCNQ2 channels in the ER."

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"Deletion of the ankyrin G-binding motif of KCNQ2 and KCNQ3 disrupts the channel AIS localization (Rasmussen et al., 2007)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...