IndraLab

Statements

KCNQ2 activates localization. 3 / 3
| 3
reach
"Furthermore, some KCNQ2 variants have been demonstrated to cause an improper channel localization in addition to causing a reduction in Kv7-associated current (4) and this has been suggested as an explanation to the variable response to specific treatments, including KD."
36891363
reach
"The wild type and R353G mutant channels were also found at the AIS and distal axons, regions where the A343D mutant channels and the CD4-KDEL proteins were absent (XREF_FIG), indicating that the A343D mutation in the IQ motif of KCNQ2 enhances the localization of HA-KCNQ3 and KCNQ2 channels in the ER."
25077630
reach
"Deletion of the ankyrin G-binding motif of KCNQ2 and KCNQ3 disrupts the channel AIS localization (Rasmussen et al., 2007)."
21530607