IndraLab

Statements

SHOX2 activates HCN4. 3 / 3
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"A previous study using mouse embryonic stem cells (embryoid bodies) performed by Hashem et al demonstrated that disruption of Shox2 downregulated Bmp4 and Hcn4, while addition of Bmp4 partially rescued this effect."
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"SHOX2 plays a key role in PC fate and can activate the pacemaker gene program (TBX3, ISL1, and HCN4) by repressing NKX2-5 and the working myocardial gene program [40]."
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"It could be shown that Shox2 leads to an upregulation of the cardiac pacemaker-specific ion channel HCN4 [57], which next to HCN1, is responsible for the generation of the spontaneous depolarizing pacemaker current I in sinoatrial cells [25,32,33,36]."
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