IndraLab

Statements

Cadmium atom inhibits NFKBIA. 3 / 3
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"As shown in Fig. 4 A, Cd enhanced the serine 536 phosphorylated NF-kappaB and serine32 phosphorylated I-kappaBalpha and caused the degradation of IkappaBalpha in ECV304 cells."
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"Low-dose Cd (4 muM) activates NF-kappaB by promoting the degradation of IkappaBalpha in human renal glomerular endothelial cells [XREF_BIBR]."
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"Interestingly, Cd did not trigger the degradation of IkappaBalpha, suggesting that Cd induced ICAM-1 expression is mediated through IkappaBalpha degradation independent pathway."
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