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USP15 inhibits TRIM25. 2 / 5

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"During human papillomavirus (HPV) infection, the E6 oncoprotein interacts with TRIM25 and ubiquitin-specific peptidase 15 (USP15), which enhances TRIM25 degradation and subsequently inhibits RLR/MAVS signaling."

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"The DENV and human papillomavirus Type 16 ( HPV16 ) suppress TRIM25 activity by USP15 to attenuate RIG-I signaling ."

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USP15 inhibits TRIM25. 2 / 5

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