IndraLab

"117 The activation of the NLRP3 inflammasome was found to be regulated by deubiquitinating proteases, but by factors upstream of the inflammasome rather than by the inflammasome itself.118The central mediators of pyroptosis are proteins from the gasdermin family.119 USP48 binds to gasdermin E (GSDME) and deubiquitinates the K48 junction at the K120 and K189 sites to stabilize GSDME, which sensitizes cancer cells to focal death and improves the response to immunotherapy.120 USP22 inhibits the activity of the NLRP3 inflammatory vesicle by promoting ATG5-mediated autophagy, which is the main mechanism to reduce the ubiquitination of the K27 and K48 site junctions and thus stabilize ATG5.121 Few studies investigated the relationship between USP and pyroptosis and the relationship between pyroptosis and BC."