IndraLab

Statements

USP22 is phosphorylated on S237. 4 / 4
1 | 3
rlimsp
"Proteomic analysis of the USP22 proteins from cells expressing the constitutively active forms of CDK1 identified two phosphorylated amino acids of USP22, S237 and T147 (Supplementary Figure S4a and S4b), both of which are conserved amino acids from Xenopus to human (Figure 4d)."
27030811
hprd
No evidence text available
19651622
rlimsp
"In addition, in vitro kinase assays confirmed that T147 and S237 are the phosphorylation sites of USP22 because co-incubation with the constitutively active form of CDK1 failed to induce USP22/AA phosphorylation (Supplementary Figure S4d)."
27030811
rlimsp
"Replacing both T147 and S237 with alanine (AA) completely abolished USP22 phosphorylation and led to decreased CCNB1 protein levels even when CDK1 was co-expressed in HCT116 cells (Figure 4e and Supplementary Figure S4e)."
27030811