IndraLab

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CDK1 phosphorylates USP29. 10 / 10
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"Regarding the fact that both USP29 and CDK1 increase the stability of TWIST1, and CDK1 phosphorylates USP29, We hypothesized that the regulation of TWIST1 by CDK1 might be mediated through the activation of USP29 in TNBC."
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"As shown in Figure  xref , active CDK1 phosphorylated GST‐fused USP29 WT, was largely abolished by the 3A mutation."
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"Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions."
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"13 We next investigated whether CDK1 could phosphorylate USP29 and affect its tumor‐promoting function in TNBC."
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"Collectively, these results suggest that CDK1 directly interacts with and phosphorylates USP29 other than TWIST1.2.5 CDK1 Regulates TWIST1 Protein Stability, CSC Self-Renewal, and Cellular Sensitivity to Chemotherapy."
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"Regarding the fact that both USP29 and CDK1 increase the stability of TWIST1, and CDK1 phosphorylates USP29, We hypothesized that the regulation of TWIST1 by CDK1 might be mediated through the activation of USP29 in TNBC."
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"Regarding the fact that CDK1 phosphorylates USP29 and USP29 stabilizes TWIST1, we hypothesized that CDK1 might also affect TWIST1 stability and function in TNBC."
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"CDK1 Binds and Phosphorylates USP29."
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"To validate that CDK1 directly phosphorylates USP29, GST‐fused USP29 WT or the 3A mutant were incubated with active CDK1 and in vitro kinase assay was performed."
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"The overexpression of CDK1 has been detected in several types of human cancers and contributes to deregulated cell cycle, DNA damage response, protein synthesis, and other cell cycle independent functions. [ xref ] We next investigated whether CDK1 could phosphorylate USP29 and affect its tumor‐promoting function in TNBC."
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