IndraLab

Statements

USP46 binds NRAS. 6 / 6
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sparser
"Similarly, the interaction of USP46 and NRAS Q61R is much stronger than NRAS WT pretreated with GDP or GTPγS (Fig. xref )."
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"The direct interaction of USP46 and NRAS mutants prompt us to examine whether USP46 is essential to regulate the stability and oncogenic function of NRAS mutants."
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"In our study, the interaction of USP46 with NRAS WT and Q61L mutant is weaker than NRAS Q61R or Q61K (Fig. xref ), which might be due to the conformation difference and charge alterations between the positively charged mutations (Q61R and Q61K) and non-polar mutation (Q61L)."
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"The endogenous interaction between USP46 and NRAS Q61R was validated in SK-MEL-103, SK-MEL-30 and SK-MEL-2 cells, respectively (Fig. xref and Supplementary Fig.  xref )."
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"We also examined the interaction between purified USP46 and different NRAS mutants."
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"The basic amino acids K61 and R61 could form a salt bridge with the acidic residue E333 of USP46, thereby enhancing the interaction between USP46 and NRAS Q61K/R mutants."
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