IndraLab
Statements
reach
"The research results from the Scaglione KM group demonstrate that the ubiquitin conjugating enzyme UBE2W attaches ubiquitin to the N-terminus of ataxin-3 and directs ubiquitin-degradation of ataxin-3 [24], suggesting that ubiquitin E2 enzyme may also directly bind to the substrate and promote its degradation."
reach
"PolyQ-expanded ataxin-3 and huntingtin are similarly degraded by multiple ubiquitin ligases, such as the carboxy-terminus of Hsp70-interacting protein (CHIP), which promotes degradation of polyQ proteins and reduces their aggregation in cell and animal models of SCA3 and HD (Jana et al., 2005; Miller et al., 2005)."