IndraLab

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Ubiquitin inhibits ATXN3. 2 / 4

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"The research results from the Scaglione KM group demonstrate that the ubiquitin conjugating enzyme UBE2W attaches ubiquitin to the N-terminus of ataxin-3 and directs ubiquitin-degradation of ataxin-3 [24], suggesting that ubiquitin E2 enzyme may also directly bind to the substrate and promote its degradation."

31881804

➶

reach

"Ataxin-3 limits ubiquitin chain length on CHIP substrates."

21855799

INDRA sources:

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IndraLab

Statements

Ubiquitin inhibits ATXN3. 2 / 4

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