IndraLab
Statements
sparser
"That study highlighted the role of coding and non-coding genes that were differentially expressed between SCNA subtypes of monosomy 3 uveal melanomas that were associated with metastasis. xref Five genes have been reported to be frequently mutated in uveal melanoma. xref Mutations in GNAQ and GNA11 occur early in tumor formation while BAP1 , SF3B1 , and EIF1AX mutations likely occur later in tumor progression. xref Mutation in EIF1AX is an indicator of good prognosis, whereas mutations in SF3B1 and BAP1 are associated with intermediate and poor prognosis."
sparser
"To further investigate the genetic interaction between BAP1 and SF3B1 mutations and to exclude that other alterations in Mel202 might contribute to the incompatibility with BAP1 deletion, we asked whether deletion of the SF3B1 ‐mutant allele in Mel202 cells could reverse BAP1 KO‐induced growth arrest."