IndraLab

Statements

USP18 ubiquitinates MAP3K7. 3 / 3
| 3
reach
"USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1 and TAB1 complex."
23825189
reach
"Collectively, these data suggest that USP18 targets the TAB1 and TAK1 complex and inhibits TAK1 polyubiquitination modification and kinase activity, thereby restricting TCR mediated NF-kappaB and NFAT activation and subsequent expression of IL-2."
23825189
reach
"USP18 also suppresses the activation of NF-κB by deubiquitinating TAK1–TAB1 complex [49] via Lys63-linked polyubiquitination of TAK1, triggers the activation of IKK/NF-κB [142]."
40102846