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Cyclin activates USP22. 2 / 2

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"USP22 function reverses cyclin D1 ubiquitylation; overexpression of cyclin D1 can partially rescue cell cycle arrest in USP22 knockdown cells."

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"Therefore, Bmi-1 and Cyclin D2 are important oncogenes in cancer and may mediate the promoting role of USP22 in human colon cancer.In conclusion, the present study systematically examined the oncogenic role of USP22 in human colon cancer."

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Cyclin activates USP22. 2 / 2

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