IndraLab

Statements

Voltage_gated_ion_channels activates KCNMA1. 3 / 3
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sparser
"The mechanism for KCa1.1 activation was apparent in I - V plots where a Cav3 calcium prepulse left-shifted the voltage dependence for KCa1.1 activation, a result expected due to the interplay between calcium- and voltage-gated activation of KCa1.1 channels."
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sparser
"The γ1 LRRD may play a slightly inhibitory role, or the other BKγ subunits’ LRRDs may play a slightly stimulatory role, in BK channel voltage-gated activation."
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reach
"In vascular smooth muscle, however, the close vicinity between sarcoplasmic RyR2 (and likely RyR3 as well) and Ca /voltage-gated K channels of big conductance (BK channels) located in the sarcolemma leads to BK channel-mediated Spontaneous Transient Outward Currents (STOCs), which oppose depolarization, blunt Ca -influx and thus, oppose smooth muscle contraction while enabling myocyte relaxation and vasodilation."
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