IndraLab

Statements

BAP1 increases the amount of calcium(2+). 10 / 10
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"BAP1 can also modulate the ubiquitination and stability of IP3R3, regulating Ca release from endoplasmic reticulum and cell viability (38)."
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"Mechanistically, BAP1 interacted with IP3R and increased cardiomyocytes' Ca 2+ level, causing mPTP opening and mitochondrial dysfunction, promoting H/R-induced cardiomyocytes' ferroptosis."
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"A recent factor that deserves attention is the tumour suppressor BAP1, which has been shown to increase the amount of Ca 2+ released from the ER into the cytosol and mitochondria, promoting apoptosis XREF_BIBR and increasing aerobic glycolysis XREF_BIBR."
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"Additionally, BAP1 promotes tumor cell apoptosis by regulating ER-mitochondrial calcium release (19)."
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"In another report, BAP1 was found to modulate endoplasmic reticulum (ER)-mitochondria calcium release (4)."
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"These results indicated that BAP1 increases cardiomyocytes’ Ca level, inducing mPTP opening and mitochondrial dysfunction through interactions with IP3R."
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"BAP1 stabilizes type 3 inositol-1,4,5-triphosphate receptor, promoting Ca release from the endoplasmic reticulum (ER) [42]."
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"In this study, we observed that BAP1 increased cardiomyocytes’ Ca level, causing mPTP opening and mitochondrial dysfunction through interactions with IP3R, and reversed the function of Exos inhibited H/R-induced cardiomyocytes ferroptosis."
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"Although the exact mechanism underpinning the metabolic alterations associated with BAP1 loss are currently unknown, a study from 2017 reported that BAP1 promotes calcium (Ca ) release from the ER to the mitochondria ."
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"For example, BAP1 promotes apoptosis by deubiquitinating and stabilizing IP3R3 at the endoplasmic reticulum (ER), which stimulates Ca release from the ER into the cytosol and thereby increases the mitochondrial Ca concentration and cytochrome C release ."
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