IndraLab

Statements


BAP1 increases the amount of calcium(2+). 4 / 4
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"A recent factor that deserves attention is the tumour suppressor BAP1, which has been shown to increase the amount of Ca 2+ released from the ER into the cytosol and mitochondria, promoting apoptosis XREF_BIBR and increasing aerobic glycolysis XREF_BIBR."

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"Additionally, BAP1 promotes tumor cell apoptosis by regulating ER-mitochondrial calcium release (19)."

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"Although the exact mechanism underpinning the metabolic alterations associated with BAP1 loss are currently unknown, a study from 2017 reported that BAP1 promotes calcium (Ca ) release from the ER to the mitochondria ."

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"In another report, BAP1 was found to modulate endoplasmic reticulum (ER)-mitochondria calcium release (4)."