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CYLD inhibits Neoplasm Metastasis. 11 / 12
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"CYLD inhibits proliferation and metastasis of melanoma cells in vivo."
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"In summary, these data show that reduced CYLD expression induces tumorigenicity of melanoma, and that reexpression of CYLD reduces their tumor growth and metastasis in vivo."
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"CYLD overexpression strongly suppressed the growth, proliferation, metastasis, and migration of NPC cells [135]."
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"This mechanism plays an important role for the growth of melanoma cells because stable expression of CYLD in melanoma cells reduced tumor growth and metastasis in vivo in a xenograft model."
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"Functional assays revealed CYLD inhibits NPC cell proliferation and migration in vitro and suppresses NPC tumorigenicity and metastasis in vivo by negatively regulating the NF-kB signaling pathway ."
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"Based on our results, loss of CYLD positively affects the formation of lymph vessels in melanoma and enhances metastasis, supporting the important role of CYLD especially in the early process of melanoma progression."
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"CYLD Inhibits Tumorigenesis and Metastasis by Blocking JNK and AP1 Signaling at Multiple Levels."
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"Additionally, the increased levels of Snail1 in melanoma result in the reduced expression of the tumor suppressor cylindromatosis (CYLD), which is known to inhibit proliferation and metastasis [42] ."
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"Deficiency of either Itch or CYLD, essential ubiquitin modulators for TAK1 inactivation, enhances tumor-associated macrophage-induced inflammation, tumorigenesis, and metastasis in a Lewis lung carcin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Functional assays revealed CYLD inhibits NPC cell proliferation and migration in vitro and suppresses NPC tumorigenicity and metastasis in vivo by negatively regulating the NF-kB signaling pathway."
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"Loss of CYLD up-regulates NFKB signaling and enhance metastasis in breast cancer [37]."
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