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USP22 activates inflammatory response. 4 / 4
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"Taken together, the findings of the present study have demonstrated for the first time that USP22 inhibition attenuates high glucose induced podocyte injuries and inflammation."
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"Silencing of USP22 suppressed ROS production and inflammation while inhibition of USP14 reduced the accumulation of oxidized proteins."
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"We further showed that the overexpression of USP22 increased inflammation, while knocking down BRD4 suppressed the inflammatory response in AML-12 cells."
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"Accordingly , USP22 downregulation also attenuated cerebral I / R-induced oxidative stress , inflammation , and cell apoptosis in mice , thereby reducing nerve injury and neurological dysfunction [ 20 ] ."
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