IndraLab

Statements

COPS6 activates MDM2. 3 / 3
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reach
"CSN6 enhances MDM2 stabilization and plays an essential role in promoting tumorigenesis by regulating MDM2/p53 signaling ."
35315259
reach
"CSN6 may promote carcinogenesis by positively regulating v-myc avian myelocytomatosis viral oncogene homolog (Myc) and MDM2 proto-oncogene stability, and is regarded as a potential target for cancer therapy."
27748879
reach
"Previously, Lee 's laboratory demonstrated that CSN6, a subunit of the COP9 signalosome, interacts with and inhibits the degradation of an oncogene MDM2, leading to its stabilization (XREF_FIG)."
23099920