IndraLab

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USP35 increases the amount of SREBF2. 4 / 4
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"Given that USP35 could stabilize BRPF1, we thus wondered whether USP35 could rely on BRPF1 to modulate SREBP2 expressions."
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"Given that SREBP2 regulates a series of enzymes that sustain MVA metabolism activities, we observed that USP35 depletion could down-regulate the mRNA levels of SREBP2 downstream targets, named as MVA signature, including HMGCR, FDFT1, SQLE, MSMO1, FDPS and LSS (Fig. 6A)."
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"USP35 deubiquitinates BRPF1 to activate SREBP2 expressions, thereby strengthening the MVA crosstalk in PRAD progression."
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"In line with the results, we found that USP35 could enhance SREBP2 levels, and the increase could be completely abolished by BRPF1 KD (Fig. 5J)."
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