IndraLab

Statements

AICA ribonucleotide inhibits STAT1. 4 / 4
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"AICAR reduced IFN-gamma-induced STAT1 by 36.5% +/- 3.4% in the GFP cells, and by 18.5% +/- 5.7% (n = 3, p < 0.05) in cells with reduced AMPKalpha (XREF_FIG), indicating that the AICAR mediated reduction in STAT1 occurs in an AMPK dependent manner."
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"Importantly, AICAR suppressed IFN-gamma-induced STAT1 and other inflammatory molecules at the transcriptional level."
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"AICAR significantly attenuated total STAT1 nuclear accumulation (lane 7) and retained STAT1 in the cytosol (lane 3)."
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"This regulation occurs at the mRNA level as AICAR also significantly suppressed IFN-gamma-induced STAT1 mRNA in a concentration dependent fashion (XREF_FIG)."
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