IndraLab

Statements

USP2 inhibits Imd. 4 / 4
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"However, while USP2 is also required to prevent excessive activation of the Imd pathway in infected flies, USP34 displays differential requirement depending on the antimicrobial peptide gene analysed : silencing Usp34 enhanced the activation of AttA, Drs and IM1."
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"However, while USP2 also prevents excessive Imd dependent signalling in vivo, USP34 shows differential requirement depending on NF-kappaB target genes, in response to fly infection by either Gram positive or Gram negative bacteria."
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"USP2 promotes Imd degradation by the proteasome."
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"We report here that USP2 and USP34 and Puf, in addition to the previously described USP36 and Scny, prevent inappropriate activation of Imd dependent immune signal in unchallenged conditions."
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