IndraLab

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DNMT3A increases the amount of KCNA2. 3 / 3
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"Finally, we observed whether these effects were mediated through OCT1 regulation of DNMT3a-triggered Oprm1 and Kcna2 gene expression in the DRG."
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"Our in vitro DRG neuronal culture studies further demonstrated that DNMT3a directly regulated the expression of Kcna2, but not Kcna1 and Kcna4."
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"Indeed, overexpression of DNMT3a through transduction of HSV-Dnmt3a in cultured DRG neurons of Dnmt3a mice reduced the level of Kcna2 mRNA, whereas knockdown of DNMT3a through transduction of AAV5-Cre in in vitro cultured DRG neurons of Dnmt3a mice substantially increased Kcna2 mRNA expression (Fig. 8d)."
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