IndraLab

Statements


PBRM1 inhibits BAP1. 1 / 1
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"Genetic markers of ccRCC include biallelic inactivation of Von Hippel-Lindau (VHL) tumor suppressor genes; negative regulators of hypoxia inducible factor (HIF) protein; copy number changes of chromosome 3p, 5q, and 14q genes; and chromatin modifying enzyme high mutation frequencies, such as protein polybromo-1 (PBRM1), SET domain containing 2 (SETD2), and BRCA1 associated protein-1 (BAP1) [XREF_BIBR]."