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Vitamin D inhibits NLRP3. 15 / 15
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"Higher levels of vitamin D reduce both NLRP3 activation and DNA-damaging oxidative stress."
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"Subsequent investigations have provided evidence indicating that vitamin D inhibits the activation of the NLRP3 inflammasome via a SIRT3-SOD2-mtROS signal [189]."
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"Vitamin D inhibits NLRP3 activation by impeding its deubiquitination mediated by BRCC3 45 ."
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"Vitamin D downregulates NLRP3 and protects against toxin-induced cell death 46 and modulates the NLRP3 inflammasome activation 47 ."
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"Vitamin D downregulates NLRP3 and protects against toxin-induced cell death 46 and modulates the NLRP3 inflammasome activation 47 ."
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"In addition, vitamin D has been demonstrated to inhibit NLRP3 inflammasomes through autophagy induction to treat a variety of inflammatory diseases [255,256]."
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"Notably, lifestyle interventions like aerobic exercise and dietary supplements, including vitamin D, quercetin, and baicalin, also reduce vascular inflammation via NLRP3 pathways [217,226,227,228,229], emphasizing the importance of integrative approaches in managing this condition.In summary, these preclinical models shed light on key mechanisms, including harmful processes such as oxidative stress, inflammation, and NLRP3 inflammasome activation, as well as protective pathways like the nitrate-nitrite-NO cascade and the SIRT1-eNOS axis."
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"Furthermore, several studies reported vitamin D inhibits NLRP3 inflammasome pathway in other disease models ( Jiang et al., 2021 ; Duan et al., 2021 ), and VDR as a negative regulator of NLRP3 oligome[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Next, the mRNA levels involved in NLRP3 components and serum IL-1β concentration were analyzed to determine whether vitamin D decreased NLRP3 inflammasome-associated pro-inflammatory cytokine production, ATM, and systematic inflammation."
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"Vitamin D has been found to inhibit the NLRP3 inflammasome either by direct binding between NLRP3 and the Vitamin D receptor (VDR) (26) or via VDR signaling-mediated inhibition of cytokine secretion (27)."
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"Zhang et al. demonstrated that vitamin D treatment effectively suppressed the overactivation of the NLRP3 inflammasome and pyroptosis induced by MASLD, thereby alleviating hepatic injury caused by a HFD [127]."
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"This study aimed to explore whether vitamin D inhibits NLRP3 activation, thus helping to mitigate heat stress damage to testicular spermatogenic and Sertoli cells."
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"Vitamin D has been shown to inhibit the NLRP3 inflammasome either by direct binding between NLRP3 and VDR (26) or via VDR signaling-mediated inhibition of cytokine secretion (27)."
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"In monocytes from preeclampsia-affected pregnant women, progesterone and vitamin D inhibited the activation of the TLR4-MyD88-NF-κB pathway and the NLRP1/NLRP3 inflammasomes (165)."
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"We also showed that vitamin D inhibited AII- or ET-induced cell proliferation and the key cell cycle determinant Cdc25A expression in VSM cells [ xref , xref ], as well as activated natriuretic peptide receptor A expression in VSM cells, and inner medullary collecting duct cells in vitro and in vivo [ xref , xref ]."
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