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BRL-32872 inhibits KCNH2. 2 / 2

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"Using the two-microelectrode voltage clamp technique, we found that BRL-32872 caused a high-affinity, state dependent block of open HERG channels (IC (50) = 241 nM) in a frequency dependent manner with slow unbinding kinetics."

11303067

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"BRL-32872 inhibited HERG currents in HEK 293 cells in a dose dependent manner, with an IC (50) value of 19.8 nM."

11303067

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IndraLab

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BRL-32872 inhibits KCNH2. 2 / 2

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