IndraLab

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USP29 increases the amount of 9b. 5 / 5
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"The results showed that overexpression of ORF9b increased the SARS-CoV-2 trVLP infectivity, whereas USP29 further enhanced the SARS-CoV-2 trVLP infectivity by upregulating the expression of ORF9b (Fig. 7A)."
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"As expected, overexpression of USP29 increased the expression of ORF9b, resulting in stronger IFN-β and NF-κB inhibition than ORF9b alone (Fig. 5A and B)."
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"Accordingly, USP29 WT but not C294A increased the expression of ORF9b (Fig. S4A-B)."
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"In contrast, knockdown of USP29 reduced the expression of ORF9b, thereby releasing IFN-β induction and NF-κB activation (Fig. 5G–H)."
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"As expected, USP29 increased ORF9b expression (Fig. 6E)."
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