IndraLab

Statements

OTUD3 activates Deubiquitinase. 2 / 2
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"Mechanistically, acetylation of the core OTU domain in OTUD3 markedly enhances deubiquitinase activity on MAVS (mitochondrial antiviral-signaling protein), thereby inhibiting the innate antiviral immune response."
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"While OTUD3 acetylation promotes its DUB activity, its deacetylation by SIRT1 inhibits MAVS deubiquitination following viral infection, thus promoting activation of innate immune signaling (162)."
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