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USP19 activates PAH-R243Q. 1 / 1

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"We also demonstrate that USP19 deubiquitinates and rescues both the R241C and R243Q PAH variants from rapid protein degradation, whereas inhibiting USP19, either by sgRNA-mediated knockdown or by broad spectrum DUB inhibitor, promoted the ubiquitination of these two PAH variants."

35987969

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IndraLab

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USP19 activates PAH-R243Q. 1 / 1

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