IndraLab

Statements

KCNH2-E637K activates endoplasmic reticulum. 3 / 3
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"Since Calnexin and Calreticulin are chaperone proteins with important regulatory roles in the ER quality control pathways, we want to test whether the trafficking deficient G572R-hERG and E637K hERG mutants can activate ER stress responses."
22242185
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"We demonstrated that trafficking deficient G572R-hERG and E637K hERG mutant proteins activate ER stress pathways and target the proteasome for degradation."
29752336
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"These results suggest that trafficking deficient G572R-hERG and E637K hERG mutant proteins can activate ER stress pathways and are targeted to the proteasome for degradation."
22242185