IndraLab

Statements

KCNH2-E637K activates endoplasmic reticulum. 3 / 3
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reach
"These results suggest that trafficking deficient G572R-hERG and E637K hERG mutant proteins can activate ER stress pathways and are targeted to the proteasome for degradation."
22242185
reach
"We demonstrated that trafficking deficient G572R-hERG and E637K hERG mutant proteins activate ER stress pathways and target the proteasome for degradation."
29752336
reach
"Since Calnexin and Calreticulin are chaperone proteins with important regulatory roles in the ER quality control pathways, we want to test whether the trafficking deficient G572R-hERG and E637K hERG mutants can activate ER stress responses."
22242185