IndraLab

Statements

USP19 activates autophagy. 11 / 11
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"For example, USP6/TRE17 is involved in activation of NF-κB pathway [ 24 , 25 ]; USP8 regulates T cell homeostasis and mitophagy in mitochondria [ 26 , 27 ]; USP10 or USP42 regulates p53 localization a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The IP results in this study showed that USP19 interacts with the Beclin1 protein to initiate autophagy in cells."
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"The researchers found that USP19 promoted autophagy and thus downregulated NLRP3 inflammasome activation."
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"TIPE3 upregulates the expression of USP19, enhancing autophagy."
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"Interaction of USP19 and Beclin1 induced by TIPE3 promotes cellular autophagy."
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"In addition, USP19 induces autophagy through deubiquitination of beclin1 [42]."
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"Consistent with this finding, a study has shown that the deubiquitinase USP19 stabilizes Beclin-1 by removing the K11-linked ubiquitin chains from Beclin-1, and positively regulates autophagy ."
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"By removing K11 linked chains at K437 from Beclin-1, an essential factor of autophagic initiation, USP19 induces autophagy and inhibits the production of type I IFN [XREF_BIBR]."
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"Resveratrol also inhibits autophagy, mediated by ubiquitin-specific peptidase 19 (USP19)-Beclin1, to minimise ferroptosis (102)."
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"USP19 positively regulates autophagy by stabilizing Beclin-1, an essential autophagy protein, via deubiquitination [27]."
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"Furthermore, TIPE3 upregulated USP19 protein expression, which accelerated autophagy."
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