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USP15 activates Lymphatic Metastasis. 3 / 3
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reach
"Recently, a study indicated that MFSD4A-AS1 activated transforming growth factor (TGF)-β signaling by sponging miR-30c-2-3p that targeted TGFBR2 and USP15, which promoted lymphangiogenesis and lymphatic metastasis of PTC 31."
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reach
"Mechanistic dissection further revealed that MFSD4A-AS1 functioned as competing endogenous RNA to sequester miR-30c-2-3p, miR-145-3p and miR-139-5p to disrupt the miRNA-mediated inhibition of vascular endothelial growth factors A and C, and further activated transforming growth factor (TGF)-beta signaling by sponging miR-30c-2-3p that targeted TGFBR2 and USP15, both of which synergistically promoted lymphangiogenesis and lymphatic metastasis of PTC."
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reach
"In the current study, our results found that MFSD4A-AS1 functioned as ceRNA to sequester miR-30c-2-3p, miR-145-3p and miR-139-5p to disrupt the miRNA-mediated inhibition of VEGFA and VEGFC on the one hand; on the other hand, MFSD4A-AS1 further activated TGF-β signaling by sponging miR-30c-2-3p to relieve the repressive effect of miR-30c-2-3p on TGFBR2 and USP15, which synergistically promoted lymphangiogenesis and lymphatic metastasis of PTC."
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