IndraLab

Statements

CTNNB1 increases the amount of USP1. 6 / 6
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"Taken together, these results demonstrate that β-catenin transcriptionally activates USP1 expression to promote EZH2 protein level in glioma."
30425057
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"Beta-catenin and TCF4 activated transcription of the deubiquitinase USP1, which then interacted with and deubiquitinated EZH2 directly."
30425057
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"Beta-catenin/TCF4 activated transcription of the deubiquitinase USP1, which then interacted with and deubiquitinated EZH2 directly."
30425057
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"We found that β-catenin induced the expression of USP1, which then interacted and deubiquitinated EZH2 directly to suppress the ubiquitin-proteasomal degradation of EZH2."
30425057
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"Gain of function and loss of function experiments indicate that β-catenin positively regulates the expression of USP1."
32723561
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"These results suggest that β-catenin activates USP1 transcription."
30425057