IndraLab

Statements

OTULIN inhibits GZMM. 4 / 4
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"Conversely, OTULIN overexpression suppressed Met1-Ub of RIPK2 in a manner dependent on its catalytic activity."
23806334
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"To directly address if OTULIN antagonizes NF-kappaB activation by disassembling Met1-Ub, we devised a system whereby a noncleavable (Gly76 --> Ser76; GS) Met1-Ub was docked to XIAP via an IAP binding [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23806334
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"Contrary to this, OTULIN functions to restrict the accumulation of Met1-Ub at basal conditions and early during signaling, and OTULIN expression is not induced by stimulation of NF-kappaB activity."
26997266
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"In contrast, our data suggest that OTULIN functions to restrict Met1-Ub accumulation and regulate early signaling processes."
23806334