IndraLab

Statements

USP19 binds HSPA8. 9 / 9
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reach
"USP19, a previously uncovered MAPS regulator binds HSC70 and acts upstream of HSC70 and DNAJC5."
29531792
sparser
"The fact that neither the peri-nuclear localization of DNAJC5 nor its MAPS-stimulation activity depends on the J-domain raises the possibility that HSPA8 may collaborate with USP19 directly during substrate recruitment considering the reported interaction of USP19 with HSPA8 [ xref ]."
35506243
reach
"USP19 interacts with HSC70."
29531792
reach
"However, whether HSC70 interacts specifically with endogenous USP19 in untransfected cells was unclear."
29531792
sparser
"The observed interaction of USP19 with HSC70 prompted us to investigate whether DNAJC5–HSC70 uses the MAPS pathway to enhance Tau and α-Syn secretion."
29531792
sparser
"USP19 interacts with HSC70."
29531792
reach
"Biochemical study showed that USP19 binds to two major heat shock proteins HSC70 and HSP90 in cells, suggesting a possible role in PQC (Lee et al., 2014)."
35620055
sparser
"However, whether HSC70 interacts specifically with endogenous USP19 in untransfected cells was unclear."
29531792
biogrid
No evidence text available
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