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USP22 activates fatty acid biosynthetic process. 3 / 3
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"In contrast, other studies have shown that USP22 promotes fatty acid synthesis in hepatocellular carcinoma cells and, thus, hepatocellular carcinoma progression ."
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"In addition, we find that USP22 promotes de novo fatty acid synthesis and contributes to HCC tumorigenesis, however, this tumorigenicity is suppressed by inhibiting the expression of PPARγ, ACLY, or ACC in in vivo tumorigenesis experiments."
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"In p53 wild-type colorectal cancer (CRC) cells, hydrogen peroxide (H 2 O 2 )-induced p53 expression represses the transcription of deubiquitinase USP22, which otherwise deubiquitinates and stabilizes Fatty Acid Synthase (FASN), and thus inhibits fatty acid synthesis."
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