IndraLab

Statements

FOXO3 increases the amount of BAP1. 9 / 9
| 9
reach
"To further clarify the regulatory effect of FOXO3a on BAP1, western blotting showed that silencing FOXO3a significantly inhibited the expression level of BAP1 protein in neurons after SAH, and increased the expression of H2Aub and SLC7A11 (Fig. 4J–L)."
40080966
reach
"qPCR also found that silencing FOXO3a significantly inhibited BAP1 mRNA levels and increased SLC7A11 mRNA levels after SAH (Fig. 4M–N)."
40080966
reach
"Immunofluorescence also appeared that silencing FOXO3a significantly inhibited the expression level of BAP1 protein in neurons after SAH (Fig. 4O)."
40080966
reach
"Immunofluorescence also revealed that FOXO3a overexpression further increased the protein expression level of BAP1 in HT22 cells (Fig. 5C)."
40080966
reach
"These results indicated that FOXO3a was activated in hemin-treated HT22 cells, and silencing FOXO3a effectively inhibited the expression of BAP1 and increased the expression level of SLC7A11.3.5 Overexpressed FOXO3a aggravated neuronal ferroptosis after treatment with hemin."
40080966
reach
"The FOXO3a overexpression plasmid was also used to transfect HT22 cells, qPCR showed that overexpression of FOXO3a significantly increased the mRNA transcription of BAP1 and inhibited the mRNA level of SLC7A11 after treatment with hemin (Fig. 5A–B)."
40080966
reach
"After treatment with hemin, FOXO3a overexpression significantly increased the expression of FOXO3a and BAP1 proteins, and inhibited the protein expressions of SLC7A11 and GPX4 in HT22 cells (Fig. 5D–F)."
40080966
reach
"Overexpression of FOXO3a could increase the expression of BAP1 and aggravate ferroptosis in neurons."
40080966
reach
"Silencing FOXO3a significantly suppressed the expression of BAP1, modulated the levels of SLC7A11 and GPX4, and attenuated the level of lipid peroxidation and mitochondrial damage in neuron."
40080966