IndraLab

Statements

USP5 activates Pain. 4 / 4
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"USP5 modulates neuropathic and inflammatory pain by increasing the stability of Cav3.2 protein [11, 12]."
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"This neuronal-activity-induced USP5 upregulation may underlie a protective, transient sensitization of the pain pathway."
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"The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity."
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"We showed that depletion of USP5, or its uncoupling from Cav3.2 channels via delivery of Tat peptides prevented and/or reversed the pain phenotype in models of peripheral inflammation (i.e., formalin and CFA) and peripheral nerve injury (i.e., partial sciatic nerve ligation)."
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