IndraLab

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USP5 activates Pain. 7 / 7
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"The down-regulated genes include Usp5, which modulates neuropathic and inflammatory pain ; Tuba1a, which is necessary for central nervous system development and regeneration ; Csf1r, which promotes microglial proliferation ; and Slc39a6, which is found in reactive astrocytes."
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"The down-regulated genes include Usp5 which modulates neuropathic and inflammatory pain [83], Tuba1a which is necessary for central nervous system development and regeneration [84], Csf1r which promotes microglial proliferation [85, 86], and Slc39a6 which is found in reactive astrocytes [87]."
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"The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity."
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"USP5 can interact with the Cav3.2T-type channel protein to modulate the neuropathic and inflammatory pain [10] ."
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"We showed that depletion of USP5, or its uncoupling from Cav3.2 channels via delivery of Tat peptides prevented and/or reversed the pain phenotype in models of peripheral inflammation (i.e., formalin and CFA) and peripheral nerve injury (i.e., partial sciatic nerve ligation)."
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"A variant was identified in the gene encoding for the deubiquitinating enzyme USP5 (P3), that modulates neuropathic and inflammatory pain by interacting with calcium channels also implicated in postherpetic neuralgia (García-Caballero et al., 2014; Li et al., 2021)."
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"USP5 modulates neuropathic and inflammatory pain by increasing the stability of Cav3.2 protein [11, 12]."
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