IndraLab

Statements


USP28 activates USP28. 2 / 2
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"These findings suggested that ATM mediated phosphorylation of USP28 promotes dissociation of USP28 from KLHL2, destabilizing UCK1."

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"Nickel ions or hypoxia could impact the de-ubiquitination process by directly inhibiting USP28 activity or indirectly decreasing USP28 activity through either the dissociation of USP28 from the c, Myc, and Fbw7alpha complex or by a reduction of cellular USP28 levels."