IndraLab

Statements

USP28 activates USP28. 4 / 4
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"Loss of USP28 promotes MYC ubiquitination (45), predicting a diminished MYC-PAF1 interaction and enhanced expression of MYC target genes in USP28-deficient cells."
38227944
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"However, a trend towards increased USP28 protein expression was detected in CD3/CD28 activated helper T cells at 72h compared to resting naïve T cells ( Figure 1C ), suggesting that USP28 protein levels are induced by T cell activation.To better understand the role of USP28 in T cells, USP28 knockout (USP28 ) and their littermate control mice (USP28 ) were generated as previously described (24)."
39076972
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"Nickel ions or hypoxia could impact the de-ubiquitination process by directly inhibiting USP28 activity or indirectly decreasing USP28 activity through either the dissociation of USP28 from the c, Myc, and Fbw7alpha complex or by a reduction of cellular USP28 levels."
20046830
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"These findings suggested that ATM mediated phosphorylation of USP28 promotes dissociation of USP28 from KLHL2, destabilizing UCK1."
31938050