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UCHL3 activates CUL1. 2 / 2
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"However, we found that knockout of COPS5 abolished the effect of UCHL3 on Cullin1 deneddylation, indicating that COPS5 is required for UCHL3 mediated deneddylation of Cullin1 in cells."

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"Subsequently, UCHL3 mediated upregulation of COPS5 promotes Cullin1 deneddylation."