IndraLab

Statements

USP11 activates E7. 2 / 2
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"USP11 promotes cervical cancer progression and proliferation through deubiquitination and stabilization of HPV-16E7, subsequently affecting the biological function of E7 as well as the HPV-16E7 contribution to cellular transformation [104] (Fig. 4)."
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"Over expression of USP11 increases the half-life of E7 while siRNA knockdown of USP11 enhanced E7 degradation with a concomitant loss of E7 transforming activity in CaSki cells."
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