IndraLab

Statements

USP15 activates Ubiquitin. 5 / 7
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"Depletion of USP15 with two independent siRNA oligos does not interfere with this basic ubiquitylation ladder but promotes the appearance of an additional higher molecular weight ubiquitin smear above the 116-kDa marker that is indicative of the accumulation of distinct polyubiquitylated species of BRAP in the absence of USP15."
23105109
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"These results suggest that USP15 prevents the ubiquitin dependent degradation of MDM2 in activated T cells."
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"We previously revealed that USP15 promotes Th17 differentiation through removing a ubiquitin chain conjugated to Lys446 of RORγt which prevents the recruitment of SRC1 ."
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"In contrast, USP15 readily accepts different types of ubiquitin chains (24) and a broader range of substrates (25)."
37777157
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"The DUSP-Ubl portion of USP15 enhances ubiquitin exchange (Clerici et al, 2014), and DUSP is not found in any non-USP domain architectures."
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