IndraLab

Statements

USP4 activates CRC. 8 / 8
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"Knockdown of USP4 suppresses CRC stemness and inhibits resistance to oxaliplatin."
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"Further experiments found that overexpression of USP4 could significantly enhance the migration and invasion of CRC and promote the expression of stemness-related genes such as SOX9, OCT4, and CD133."
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"Given that CSCs are implicated in drug resistance, we hypothesized that USP4 might enhance chemoresistance in CRC."
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"These data indicates that USP4 facilitates the migration and invasion of CRC, and further promotes CRC development."
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"USP4 promotes CRC stemness via upregulating SOX9 expression."
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"These data indicates a relevant role of USP4 in CRC stemness via modulating SOX9 expression.Rescuing experiment was performed to verify the critical role of SOX9 in mediating USP4 induced CRC stemness."
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"Taken together, these data demonstrate that SOX9 is a critical downstream element in USP4-induced CRC stemness."
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"Moreover, USP4 markedly promoted CRC stemness via upregulating SOX9 (Fig. 2B)."
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