IndraLab

Statements

USP10 activates MDM2. 3 / 3

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"However, coexpression of USP10 or HAUSP, but not USP10 CA or USP10Delta1-100, significantly reversed the inhibitory effect of Mdm2 on p53 mediated apoptosis."

20096447

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reach

"In contrast to USP7 and USP2a, USP10 specifically deubiquitinate p53 because knockdown of USP10 in HCT116 p53-/- cells does not cause Mdm2 reduction [XREF_BIBR]."

28031783

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sparser

"The DUB USP10 interacts with the ubiquitin ligase MDM2 and activates MDM2 by removing the MDM2 polyubiquitination chain."

40225869

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IndraLab

Statements

USP10 activates MDM2. 3 / 3

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