IndraLab

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BRCC3 inhibits apoptotic process. 4 / 4
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"Besides, BRCC3 could activate NLRP3 inflammasome-dependent pyroptosis (26), which could then promote tumor progression.In conclusion, UCA1 acted as an oncogene in pancreatic cancer by partly regulating miR-582-5p/BRCC3, which promoted cell proliferation, migration, and inhibited apoptosis."
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"Consistently, treatment with thiolutin, an inhibitor of BRCC36, specifically suppressed cell proliferation and induced cell apoptosis in ITD cells."
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"Liu et al. reported that BRCC36 inhibition induced apoptosis in internal-tandem duplication domain (ITD)-positive cells [33]."
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"Our study was the first to report the function of BRCC3 in pancreatic cancer, which found that downregulation of BRCC3 inhibited the cell proliferation, metastasis and induced apoptosis."
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